Dongsheng Chiral has set up a special custom synthesis department with many core technical researchers and has the ability to quickly deliver with the concerted efforts of the project department. We can provide custom synthesis of milligram to kilogram products including advanced intermediates, standard compounds, molecular module fragment synthesis, and literature compounds. The high order delivery rate and product quality have earned us deep trust from our customers.

We have a large library of catalog compounds for small molecule pharmaceutical intermediates. We can offer milligrams to kilograms of products (in stock or for fast delivery).

Based on the strong chemical synthesis capability and mature analytical platform of Dongsheng Chiral, we can provide custom synthesis and isolation and purification of chiral compounds and standards with high optical purity.

Lanzhou Yaocheng, the production base of Dongsheng Chiral Pharma, is located in Lanzhou National SRDI New Chemical Industry Park. It has a workshop with high standard construction. The size of the reaction kettle ranges from 5L to 5,000L, and it can deal with a series of challenging and difficult reactions such as low-temperature reactions (as low as -100℃), high-temperature reactions (200℃), and high-pressure reaction (100 ATM), non-precious metal catalysis et al. Our strong production capacity and flexible workshop arrangement can quickly provide solutions at any stage of a customer project, whether it is pre-clinical toxicology batch production in kilograms, clinical phase production in tens of kilograms or commercial production in tonnage.
For time-sensitive customers such as CRO and clinical batch products, the good versatility of the workshop, the rapid switch of flexible capacity and the project-based management mode ensure that the production and operation system can quickly deliver the products and services required by customers with high-quality.

Dongsheng Chiral has an experienced registered declaration team and its members have a good command of modules and specialized knowledge. From the early stages of drug development, overall CMC, clinical research and internal follow-up, they provide simultaneous assessment, planning and feasibility consulting and compliance guidance and support, to ensure that the data meets the requirements of the regulators. Being familiar with perfect official communication channels, we greatly grasp the regulatory guidelines and review requirements, ensure the quality of submitted documents to meet the application requirements, and accelerate drug registration and approval.

Asymmetric hydrogenation - Catalyst screening
Research and technology development of novel asymmetric catalytic reactions
Screening of chiral auxiliaries/reagents
A new method of chemical resolution

Enzyme screening
Enzyme catalyzed and resolution
Enzyme asymmetric catalytic reaction

High-Performance Liquid Chromatography (HPLC)
Liquid Chromatograph-Mass Spectrometer (LC-MS)
Gas Chromatography/Gas Chromatograph-Mass Spectrometer (GC /GC-MS)
Supercritical Fluid Chromatography (SFC)
Special polarimeter(ORD)
Structure characterization (HNMR, CD, SC-XRD)
Hydrogen Nucleus Magnetic Resonance (HNMR)